The Electrospray Ionization Source is a know application in tandem with LC/MS. It is generally utilized for evaluation of analytes that may be tiny or large. However, with Agilent Technologies manufacturing this particular source, the source itself makes use of an exclusive heated counter-flowing drying gas system, and an orthogonal nebulization technology. This is done for deriving high-quality operational performance. It is capable of producing negative and positive ions, and is also able to switch ion polarity on a scan-by-scan basis for duplicating single run’s amassed data.