I’ve blogged about the critical need to develop new antibiotics. Bacteria and other harmful microbes are becoming increasingly immune to existing medications.
Case in point: The World Health Organization reports that gonorrhea is becoming impossible to treat. “Some countries – particularly high-income ones, where surveillance is best – are finding cases of the infection that are untreatable by all known antibiotics,” WHO says.
Gonorrhea is a sexually transmitted disease that infects 78 million people a year. It disproportionally affects women, with effects that include pelvic inflammatory disease, infertility and an increased risk of HIV.
“The bacteria that cause gonorrhea are particularly smart,” says WHO’s Dr. Teodora Wi. “Every time we use a new class of antibiotics to treat the infection, the bacteria evolve to resist them.”
Scientists in South Africa used an Agilent Bioanalyzer System in their discovery of the country’s first cases of Neisseria gonorrhoeae resistant to cefixime, ciprofloxacin, penicillin and tetracycline.
Scientists in Europe used an Agilent Diode Array Detector in their study of the defense mechanisms employed by Nesseria gonorrhoeae during colonization and infection.
Scientists in India developed a simple, fast and novel method to quantify Amoxicillin, Ampicillin and Cephalexin in combined dosage forms. Their method uses an Agilent HPLC equipped with a binary pump, autosampler, column oven and software.
And scientists in Brazil have studied the antimicrobial activity of Jacaranda cuspidifolia Mart, a traditional medicinal plant used as an anti-syphilis and anti-gonorrhea treatment. They used an Agilent column in their work.
For more information go to:
- Antibiotic-resistant gonorrhoea on the rise, new drugs needed (World Health Organization)
- Phenotypic and genetic characterization of the first two cases of extended-spectrum-cephalosporin-resistant Neisseria gonorrhoeae infection in South Africa and association with cefixime treatment failure
- Biochemical characterization of the bacterial peroxidase from the human pathogen Neisseria gonorrhoeae
- Qualitative Analysis of Amoxicillin, Ampicillin, Cephalexin by Quadrupole –Time of Flight (LCMS) Using Electrospray Ionization (PDF)
- Jacaranda cuspidifolia Mart. (Bignoniaceae) as an Antibacterial Agent
- Agilent Pharma & Biopharma Solutions