NEW MATERIAL FOR DRUG DELIVERY

mofs-as-drug-carrierA new material that delivers drug into human body has been developed. These are porous crystalline inorganic solid materials with regular honeycomb-like structures which can be prepared in the laboratory from organic molecules which form the links between metal atoms. MOFs have the surface area of a football field in just one gram. Combining this with their porosity make them attractive potential carriers.

Several research works have been carried out on how to improve the delivery and the effectiveness of drugs. Therefore, development of an effective absorptive material for efficient loading and delivery of drugs is of great importance in both life and pharmaceutical sciences. MOFs have been used to deliver many drugs (such as Azidothymidine Triphosphate, Benzophenone-4, Busulfan, Caffeine, Cidofovir, Dodorudicin, Ibuprofen, and Urea etc.) due to their important properties. MOFs exhibit many desired characteristics as drug carriers, including exceptionally high surface areas and large cavity sizes for drug encapsulation, intrinsic biodegradability as a result of relatively labile metal–ligand bonds, and versatile functionality for post-synthetic grafting of drug molecules.

The efficacy of some anti-cancer treatments could potentially be increased and side-effects reduced by improved transport and specific delivery of drugs to the tumour site. In addition, MOFs can have multiple pore types with different characteristics and also exposed metal sites where molecules can coordinate, so the inclusion of multiple bioactive molecules in the same carrier may be possible.

Agilent’s technologies and instruments can monitor the loading and delivery of drug.  An Agilent 1260 infinity II HPLC with a VWD provides a fully integrated analytical system with extremely high sensitivity.

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